A rapid and convergent synthesis of the integrastatin core.

نویسندگان

  • Pamela M Tadross
  • Pradeep Bugga
  • Brian M Stoltz
چکیده

The tetracyclic core of the integrastatin natural products has been prepared in a convergent and rapid manner. Our strategy relies upon a palladium(II)-catalyzed oxidative cyclization to form the central [3.3.1]-dioxabicycle of the natural product core. Overall, the core has been completed in only 4 linear steps from known compounds.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Synthesis and characterization of transition metal doped ZnSe/ZnS nanocrystals by a rapid photochemical method

In the present work, a one pot, rapid and room temperature photochemical Synthesis of transition metal (TM; Cu, Mn, Cr)-doped ZnSe/ZnS core/shell nanocrystals (NCs) was reported. FT-IR spectrum confirmed the capping of ZnSe by thioglycolic acid. XRD and TEM analysis demonstrated zinc blende phase NCs with an average size of around 3 and 5 nm for TM:ZnSe and TM:ZnSe/ZnS NCs, respectively. PL spe...

متن کامل

Fe2+ Supported on Hydroxyapatite-core-shell-γ-Fe2O3 Nanoparticles as an Inexpensive and Magnetically-recoverable Catalyst for Rapid Synthesis of Benzimidazoles and Benzoxazole Derivatives

A simple and facile method for the preparation ofFe2+ supported on hydroxyapatite-core-shell-γ-Fe2O3 nanoparticles (γ-Fe2O3@HAp-Fe2+ NPs) as an environmentally friendly and recyclable green catalyst is described and used for the one-pot synthesis of benzimidazoles and benzoxazole derivatives via reactions between aromatic aldehyd...

متن کامل

Synthesis and characterization of supramolecule self-assembly polyamidoamine (PAMAM) G1-G1 NH2, CO2H end group Megamer

Supramolecule self assembly polyamidoamine (PAMAM) dendrimer refers to the chemical systems made up of a discrete number of assembled molecular subunits or components. These strategies involve the covalent assembly of hierarchical components reactive monomers, branch cells or dendrons around atomic or molecular cores according to divergent/convergent dendritic branching principles, systematic f...

متن کامل

Short Convergent Synthesis of the Mycolactone Core Through Lithiation-Borylation Homologations.

Using iterative lithiation-borylation homologations, the mycolactone toxin core has been synthesized in 13 steps and 17% overall yield. The rapid build-up of molecular complexity, high convergence and high stereoselectivity are noteworthy features of this synthesis.

متن کامل

Synthesis and Characterization of ‎Carboxymethyl Cellulose/Polystyrene ‎Core-Shell Nanoparticles by Miniemulsion ‎Polymerization

The first stage to have access to a reservoir is the drilling operation. The proper development of this operation plays a major role in increasing productivity. It must be pointed out that the drilling fluid (mud) is pivotal in achieving this objective. Among these fluids, water-based fluids are the most common ones, which have been utilized to drill approximately 80% of all wells and are m...

متن کامل

ذخیره در منابع من

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 9 15  شماره 

صفحات  -

تاریخ انتشار 2011